I-Berberine Hydrochloride
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Ulwazi oluSisiseko
Igama lemveliso: I-Berberine Hydrochloride
Igama leKhemikhali:5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
Ifomula yeMolekyuli: C₂₀H₁₈ClNO₄
Inombolo ye-CAS:【 633-65-8】
Ubunzima beemolekyuli: 372.822
Ukunyibilika: Inyibilika lula emanzini abilayo, inyibilika kancinci emanzini abandayo, kwaye ayinyibiliki phantse kwi-ethanol ebandayo, i-chloroform, kunye ne-ether.
Umgangatho woMgangatho: Yenzelwe umthengi yiCP2020,JP
Inkcazo
Izinto zovavanyo | Umgangatho |
I-Berberine Hydrochloride 【633-65-8】 | ≥97.0% nge-HPLC |
Ilahleko yokomisa | ≤12.0% |
Intsalela ekutshisweni | ≤0.2% |
Ezona mpawu
Iingenelo zeMisebenzi emininzi
Ulawulo lweMetabolic: Ivula iindlela ze-AMPK ukuxhasa ulawulo lweswekile kunye ne-lipid egazini, ifanelekile kubantu abanesifo seswekile okanye abatyebe kakhulu.
I-Antimicrobial kunye ne-Anti-inflammatory: Ithintela iintsholongwane ezifana ne-E. coli kunye ne-Staphylococcus aureus, inceda ekusulelekeni ngamathumbu.
Impilo Yamathumbu: Iguqula i-intestinal microbiota, inciphisa urhudo kunye nokungagaywa kakuhle kokutya.
Imvelaphi yendalo
Ivela kwiimifuno zonyango, idibanisa ukusebenza kakuhle kwemveli kunye nokuqinisekiswa kwesayensi.
Ubunyulu obuphezulu
Ukucocwa okuphucukileyo kuqinisekisa ubunyulu obuyi-≥98% ukuze kusebenze kakuhle kwaye kuzinze.
i-antibacterial ye-spectrum yendlela
Ichasene neentsholongwane ezahlukeneyo zeGram-positive neGram-negative (umz. iShigella, iEscherichia coli, iStaphylococcus aureus, iHemolytic streptococcus, ipneumococcus, ityphoid bacilli, njl.
Iziphumo ze-Pharmacological Ubuninzi obuluhlaza
I-Berberine hydrochloride inefuthe elibanzi le-antibacterial, kwaye indlela esebenza ngayo ibandakanya ikakhulu:
1. Ukuphazamisana nemetabolism yebhaktiriya: Ukuthintela inkqubo ye-oxidation kunye ne-decarboxylation ye-pyruvate, ikhonkco eliphakathi kwimetabolism yeswekile yebhaktiriya.
2. Ukuthintela ukuphindaphinda kwe-DNA yebhaktiriya Kuchaphazela imetabolism ye-nucleic acid yebhaktiriya kwaye kuphazamise ukwenziwa kwezinto zayo zemfuza.
3. Ukonakala kwesakhiwo sebhaktheriya: Kuyonakalisa i-membrane yeseli yebhaktheriya kwaye kuchaphazela umsebenzi wazo wokuthintela.
4. Ulawulo lokulwa nokuvuvukala kunye nolawulo lomzimba: Inefuthe elithile lokulwa nokuvuvukala kwaye inokunciphisa iimpendulo zokudumba kwamathumbu; Ezinye izifundo zibonisa ukuba inefuthe lokulawula ukusebenza komzimba wamathumbu.
5. I-Astringent kunye ne-antidiarrhea: Inefuthe le-astringent kwi-mucosa yamathumbu kwaye inciphisa ukukhutshwa kolwelo lwamathumbu.
Idosi kunye noLawulo
1. Abantu abadala: 100–300 mg, amaxesha ama-2–3 ngemini emva kokutya (dibana nogqirha ukuze ufumane idosi echanekileyo).
2. Izithintelo: Ayifanelekanga kwabasetyhini abakhulelweyo okanye izigulane ezine-hemolytic jaundice; kuphephe ukusetyenziswa ngaxeshanye namayeza e-hypoglycemic okanye ii-antibiotics (kufuneka ulwalathiso lukagqirha).
Iprofayili yoKhuseleko
Izifundo zeklinikhi zibonisa iziphumo ebezingalindelekanga ezincinci (umz., ukudumba okanye ukuqhina ngamanye amaxesha) xa kucetyiswa iidosi, ngaphandle kobungozi be-hepatorenal. Ukusetyenziswa kwexesha elide kufuneka kubandakanye ukubekwa esweni kwempilo rhoqo.
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